Simon qualified from Newcastle University and subsequently worked in clinical medicine (general, respiratory and cardiovascular) in Cardiff, Oxford and Edinburgh.
He discovered Public Health in the Scottish Office, then moved to Glasgow University before appointment as the first Professor of Clinical Epidemiology in the University of Liverpool in 1999.
Simon manages a research programme involving various aspects of clinical epidemiology, mainly cardiovascular disease (CVD). Simon and colleagues in Glasgow and Edinburgh have also published extensively on trends in CVD and stroke incidence, prevalence and survival. He enjoys contributing to policy and service work locally and nationally, and has chaired and participated in a many national and international committees including NICE, BHF, UK Faculty of Public Health and the European Society of Cardiology.